incidents de paiement ou de remboursement et faiblesse du « reste-à-vivre »). le déséquilibre budgétaire ressenti) aux critères « objectifs » (e.g. Ce travail se propose de compléter ces critères d’identification en ajoutant des critères « subjectifs » (e.g. À l’heure actuelle, pour tenter de prévenir le surendettement, les politiques publiques cherchent à identifier une population en « fragilité financière ». The potential for inhibitory interaction between sulfonylurea drugs and gut microbiota should be considered carefully in the design of future studies.ĭepuis la crise financière globale de 2008, la structure de l’endettement des ménages français connait des bouleversements : les dettes à la consommation ont progressivement été remplacées par les dettes immobilières que ce soit en termes d’encours total de dettes, ou en termes du nombre de dossiers auprès des Commissions de surendettement.
butyricum is also likely of interest to investigators of its use as a probiotic in other disease settings. To our knowledge, this is the first description of an increase in circulating butyrate or ursodeoxycholate following a probiotic intervention in humans with T2D, adding support for the possibility of a targeted microbiome-based approach to assist in the management of T2D. We show that these drugs can inhibit growth of formulation strains in vitro. Finally, improvement in HbA1c was limited almost entirely to participants not using sulfonylurea drugs. Untargeted metabolomics also revealed coordinated decreases in intermediates of fatty acid oxidation and bilirubin, potential secondary signatures for metabolic improvement. butyricum strain efficiently synthesizes ursodeoxycholate from the primary bile acid chenodeoxycholate during butyrogenic growth. In vitro monoculture experiments demonstrated that the formulation’s C. Butyrate and ursodeoxycholate increased among participants randomized to WBF-011, along with compelling trends between butyrate and glycated haemoglobin (HbA1c). Here we report targeted and untargeted metabolomic measurements on fasting plasma ( n = 104) collected at baseline and end of intervention. While the clinical endpoints were encouraging, additional exploratory measurements were needed in order to link the motivating mechanistic hypothesis - increased short-chain fatty acids - with markers of disease.
We previously reported significant improvement in postprandial glucose control in human participants with T2D following 12-week administration of a 5-strain novel probiotic formulation (‘WBF-011’) in a double-blind, randomized, placebo controlled setting (NCT03893422). An increasing body of evidence implicates the resident gut microbiota as playing a critical role in type 2 diabetes (T2D) pathogenesis.